Replies to post #448729 on Anavex Life Sciences Corp (AVXL)

[WolfofMia]

So, hindsight is 20/20.

Funny how you never mentioned these potential issues before lol.

Those two issues could have been addressed by not skimping on the trial size and using a 1:1 drug/placebo design.

[bas2020]

As I recall, the trial size decision was based on the recommendation of a highly qualified outside consultant after reviewing the AVATAR data. Nonetheless, don't you think that RAs would be quite curious to understand the reasons behind the difference in placebo results between the trofinetide trial (1.7-pt improvement) vs the Excellence trial (8.3-pt improvement)... as well as the comparison between trofinetide treatment (4.9-pt improvement) vs blarcamesine treatment (12.9-pt improvement)? No doubt they will.