Replies to post #440858 on Anavex Life Sciences Corp (AVXL)

[falconer66a]

Anavex Surely Has Aging Data Already

...what might be the first indication that A3-71 (or blarcamesine) may markedly and safely slow normal aging processes in neurons and other cells or tissues? Would you not think that Missling, being a very clever fellow (IMO), would undertake a pre-clinical trial on murines, which would not take very long if started half way (or even a third of the way) through the rodents' lives. In fact, I believe it wouldn't be unreasonable to think that he may have started such a trial already...

Good thinking. Correct.

As a practicing research biologist (primarily in restorative ecological processes), and having taught career-bound biology students destined to high-level careers in biological research, I’m familiar with contemporary biological aging research.

Doubtless, with in-force non-disclosure agreements (NDAs), Anavex has commissioned any number of in vivo (in living organisms) aging studies involving their proprietary molecules. We already know, have abundant evidence that activation of the sigma-1 receptor by Anavex molecules facilitates or restores normal autophagy in neurons and other cells. Autophagy (meaning, “self-eating”) is the cell-keeping processes where cells (especially neurons) self-consume, “eat up” and expel or digest both cell wastes and structures. Without autophagy cells age; become less functional from the accumulation of wastes and defective organelles.

So, check out the anti-aging, autophagy-restoring or supporting capabilities in appropriate lab animals. The first and easiest is in the lab roundworm Caenorhabditis elegans. The aging process of this lab animal is precisely known. Its aging can be hastened by subjecting the roundworm to various environmental factors; certain toxins or growth-medium alterations. Run such aging studies on two parallel populations; one as controls, with just the aging factors present, and another with Anavex drugs present. See if the drugs slow the aging process in any way. Stuff any biology grad student could do, in just a few months.

Do similar studies with Danio rerio, the lab zebra fish. D. rerio is a common lab animal used in aging research.

Then, of course, check aging velocities in lab rodents, mice and rats, being dosed with Anavex molecules. Instead of months, those studies can take a year or longer.

Surely, Anavex has comprehensive, trade-secret data showing the aging prophylaxis properties of their proprietary drugs. When the time is right, they will reveal what they know.