Replies to post #351 on Fate Therapeutics Inc (FATE)

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Using CRISPR screening of metabolic genes, they found that KEAP1 played an important role in the pro-inflammatory activity of macrophages through inhibiting the production of itaconate. As ACOD1 is the sole enzyme to generate itaconate, ACOD1 knockout promoted pro-inflammatory activity of macrophages and enhanced the function of CAR-Ms derived from iPSCs https://www.nature.com/articles/s41467-023-41470-9