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jondoeuk

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jondoeuk

Re: jondoeuk post# 351

Monday, 12/11/2023 5:12:58 PM

Monday, December 11, 2023 5:12:58 PM

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Using CRISPR screening of metabolic genes, they found that KEAP1 played an important role in the pro-inflammatory activity of macrophages through inhibiting the production of itaconate. As ACOD1 is the sole enzyme to generate itaconate, ACOD1 knockout promoted pro-inflammatory activity of macrophages and enhanced the function of CAR-Ms derived from iPSCs https://www.nature.com/articles/s41467-023-41470-9
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