Tred, in terms of partnerships I believe every company has their strengths and weaknesses. Missling may find that a smaller/mid-size BP, for example, is more suited as a partner for rare diseases and let a big boy handle the AD, PD, and PDD size diseases. Remember that Mayo thought that Missling might in fact be looking at a mid-size BP as a better fit as well. IMO, what Rett approval really means is that we have a recognized and approved MOA that we, and any partner, can capitalize on with other indications. The approved MOA is more the key imo.