It would honestly take very little for $AVXL to shake off it's OTC origin story and that's delivering on milestones. Trust me I'm no Dr.M superfan but will give him a fair shake.
I'm of the opinion simply reporting out on Rett and a NDA timeline will bring in some buyers and firm up $AVXL's market cap. In addition a PD trial start by the MJFF supported "Shake it Up Foundation" could do the same. It's my "hope" this can break away the sympathetic trading pattern $AVXL has with the $XBI.