Replies to post #312 on Fate Therapeutics Inc (FATE)

[jondoeuk]

Yes, a barrier to overcome to increase the depth and duration of response. One group showed that depletion of fibroblast activation protein positive cancer-associated fibroblasts helped to reduce myeloid cell accumulation and increase endogenous CD8+ T and NK cell infiltration. CLLS has developed this https://www.cellectis.com/uploads/files/SITC_2022_1.pdf

Also another that targets MUC-1 with tumour-specific IL-12 secretion https://www.cellectis.com/uploads/files/Poster_Cellectis_PE_AACR_2023.pdf

Both could be combined and should synergise together.