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jondoeuk

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jondoeuk

Re: NY1972 post# 312

Sunday, 07/16/2023 10:10:03 PM

Sunday, July 16, 2023 10:10:03 PM

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Yes, a barrier to overcome to increase the depth and duration of response. One group showed that depletion of fibroblast activation protein positive cancer-associated fibroblasts helped to reduce myeloid cell accumulation and increase endogenous CD8+ T and NK cell infiltration. CLLS has developed this https://www.cellectis.com/uploads/files/SITC_2022_1.pdf

Also another that targets MUC-1 with tumour-specific IL-12 secretion https://www.cellectis.com/uploads/files/Poster_Cellectis_PE_AACR_2023.pdf

Both could be combined and should synergise together.
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