Replies to post #606844 on NorthWest Biotherapeutics Inc (NWBO)

[Baxers]

Great summary, thanks for this!

[sentiment_stocks]

Great summary, Chiugray! :)

[hyperopia]

Excellent summary Chiugray, that’s it exactly! It was a great talk by Dr. Liau with students, and I think this discussion may be easier for some non-science investors to understand, because Dr. Liau broke down very complicated scientific studies in a way that many can understand.

As you say, I think she explained very well, how dendritic cells function, how DCVax works, what their scientific studies have shown, and what they are learning about how to improve immune response going forward, to make DCVax work better. And clearly, with the incredible long-term results those combinations are showing, that will be the regimen (DCVax-L + Poly ICLC + CSF 1R inhibitor) that will be used going forward. I can’t wait for those results to be officially published, and let the world know that there is hope for Glioblastoma patients. (and Dr. Liau is a big reason why)

[CrashOverride]

Thank you!

[Doc logic]

Chiugray,

Really, really good summary. What is interesting to me is that DCs normally provide all the signaling necessary for a complete immune response with most diseases, however, cancer causes DCs to move off site too soon for a completed immune response when introduced into any hypoxic tumor environment as a corrective treatment and prevents them from getting established in attack mode from outside the tumor by doing a good job of hiding behind normal cells while the tumor builds once pre cancerous cells and then cancer cells get past the initial immune surveillance.
Immune surveillance generally decreases as we age which is why cancer can get started in older folks easier than in most younger people but some activities or life events actually permanently build increased levels of immune surveillance with IL2 while immuno deficiencies and inherited risks can reduce a person’s immune system ability to identify or ward off cancerous cells and tumor development.
The beauty of Direct is that these DCs restore the initial immune surveillance inflammatory signaling response and with proper spacing of treatments and, like they do in other diseases, keep that signaling in place long enough for a complete immune response without the use of other things added in as long as all the cancer targets get identified which is why injecting multiple tumors is generally going to be necessary unless enough of a systemic response from identified targets is sufficient for targeting off site tumors and cancer clusters which Direct Phase 1 started to show in some cases. Best wishes.

[eagle8]

Thank you for sharing Chiugray.
Great summary.

GLTU

[Lykiri]

Great summary, thanks Chiugray!