And as you pointed out earlier, if they did choose to try freezing the leuk material in the process, they’d need to perform an equivalency study before switching.
I was reading up on this issue and the freeze thaw cycle creates damage to some cells from crystallization. Probably the same reason the lysate is made this way. Maybe more mature DCs are able to withstand this better because we know the vaccine material is cryo preserved for up to years. Best wishes.
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