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Cs are potent anti-tumoral cells that generate an immune response through presenting tumor antigens to T cells; due to this ability, DC vaccines, such as DCVax-L, are a major focus of attention for immunotherapy of gliomas21. B cells are also efficient antigen-presenting cells that act to enhance clonal expansion of tumor-specific T lymphocytes, boosting anti-tumor response22. Other anti-tumoral cells include neutrophils, which are members of the innate immune system. Their presence within the TIME has been associated with the development of resistance to anti-VEGF therapies such as bevacizumab and higher rate of metastasis23.