Replies to post #594970 on NorthWest Biotherapeutics Inc (NWBO)

[dstock07734]

ccie,

My experience with ChatGpt is that if the question falls into academic category, the answer is amazingly good, which is understandable since the peer-review papers are used to train ChatGpt. That's why I strongly believe the answers that ATL got from ChatGpt are credible ones.

I strongly believe what ATL said is right and makes perfect sense. As matter of fact, I am now thinking the objective of the following trial was to find how efficiently resiquimod and poly-iclc can mature and activate DCVax-L in vivo. Resiquimod which is gel was applied on the needle point location after DCVax-L was injected. It doesn't look like some form of treatment. Poly-ICLC neither though administered as adjuvant.

https://clinicaltrials.gov/ct2/show/NCT01204684?cond=NCT01204684&draw=2&rank=1

Here is a paper in which the author cited Steinman who was the Noble Prize winner because of dendritic cell saying that

It is now well appreciated that vaccine adjuvants act by inducing DC maturation, which improves antigen processing and presentation [9]. Several TLR agonists [Poly I:C (TLR3 agonist), MPLA (TLR4 agonist), CpG ODN (TLR9 agonist) and Resiquimod/ R848 (TLR7/8 agonist)] have thus been administered along with vaccines to deliver concomitant DC activation signals.

[9] Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature. 2007; 449:419–426.

Targeting human dendritic cells in situ to improve vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506641/

My knowledge about biology is scarce. Read it for fun.