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NY1972

05/15/23 10:55 PM

#114 RE: jondoeuk #113

Cancer is adapting. Why bother expressing ligands if the NK cells are not working anyway.

NKG2D surface down-modulation in freshly isolated NK cells from MDS patients may be a clinically useful “biomarker” of suppressed NK function.

NY1972

05/15/23 11:05 PM

#115 RE: jondoeuk #113

It will be interesting to see how this DT HER2 x NKG2D x CD16A engager works since it won't be impacted by the # of ligands on cancer cells.