Replies to post #415181 on Anavex Life Sciences Corp (AVXL)

[Joseph_K]

The authors of that article have additional relevant papers, specifically,

The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's - 2021
https://pubmed.ncbi.nlm.nih.gov/34110944/

Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain* - 2020
https://www.tandfonline.com/doi/abs/10.1080/14728222.2020.1805435?journalCode=iett20

Both those articles discuss Anavex molecules. I have not read either article.


* Introduction: The sigma receptors are found abundantly in the central nervous system and are targets for the treatment of various diseases, including Alzheimer's (AD), Parkinson's (PD), Huntington's disease (HD), depression, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). However, for many of these diseases, other receptors and targets have been the focus of the most, such as acetylcholine esterase inhibitors in Alzheimer's and dopamine replacement in Parkinson's. The currently available drugs for these diseases have limited success resulting in the requirement of an alternative approach to their treatment.

[plexrec]

falconer--thanks for your thoughtful response--"and yields positive therapeutic results for the listed CNS diseases. Nothing that cogent readers of this message board haven't previously learned."--validation from lots of places !!!! BINGO !!!! WGT !!

[abew4me]

Excellent summarization, Falconer.

"In reading the article's 42 pages of dense text this contention was validated."

Reading all of that material must've taken you at least several hours!

Thanks for all of your DD...and sharing it back with the board.

[gbrown6332]

Excellent job digesting some very dense research. Thanks...