Both those articles discuss Anavex molecules. I have not read either article.
* Introduction: The sigma receptors are found abundantly in the central nervous system and are targets for the treatment of various diseases, including Alzheimer's (AD), Parkinson's (PD), Huntington's disease (HD), depression, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). However, for many of these diseases, other receptors and targets have been the focus of the most, such as acetylcholine esterase inhibitors in Alzheimer's and dopamine replacement in Parkinson's. The currently available drugs for these diseases have limited success resulting in the requirement of an alternative approach to their treatment.
falconer--thanks for your thoughtful response--"and yields positive therapeutic results for the listed CNS diseases. Nothing that cogent readers of this message board haven't previously learned."--validation from lots of places !!!! BINGO !!!! WGT !!