“ I am hoping with Dr. Kin's input and info gleaned from the end of phase 2 study meeting with the FDA they will design a sound P3 properly powered for approval.”
Obviously you are fairly certain that the P2b/3 AD trial did not meet both endpoints...based on the data that's been presented to the public (so far).
However, can you play devil's advocate and assume that Dr. Missling is correct that both endpoints have been met...and give us the best possible scenario that would validate Dr. Missling's claim?