Replies to post #266 on Fate Therapeutics Inc (FATE)

[jondoeuk]

It has advantages as multiple edits can result in chromosomal abnormalities, but there are a number of negative regulators, so deletion could improve antitumour activity https://www.nature.com/articles/ni.3470

Another is knockdown, which DTIL was working on (haven't heard anything since this was published) https://precisionbiosciences.com/wp-content/uploads/2022/07/Pires-M-Allogeneic-CAR-T-Cells-with-Deoxycytidine-Kinase-Knockdown.-SITC.-2021..pdf