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jondoeuk

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jondoeuk

Re: NY1972 post# 266

Tuesday, 04/25/2023 11:10:01 PM

Tuesday, April 25, 2023 11:10:01 PM

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It has advantages as multiple edits can result in chromosomal abnormalities, but there are a number of negative regulators, so deletion could improve antitumour activity https://www.nature.com/articles/ni.3470

Another is knockdown, which DTIL was working on (haven't heard anything since this was published) https://precisionbiosciences.com/wp-content/uploads/2022/07/Pires-M-Allogeneic-CAR-T-Cells-with-Deoxycytidine-Kinase-Knockdown.-SITC.-2021..pdf
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