Replies to post #408478 on Anavex Life Sciences Corp (AVXL)

[nidan7500]

Thx Sokol.

So Many Dots, so little time.

Mitochondrial diseases can affect almost any part of the body, including the cells of the brain, nerves, muscles, kidneys, heart, liver, eyes, ears or pancreas.

Mitochondrial dysfunction occurs when the mitochondria don't work as well as they should due to another disease or condition. Many conditions can lead to secondary mitochondrial dysfunction and affect other diseases, including:

- [Alzheimer's disease](https://my.clevelandclinic.org/health/diseases/9164-alzheimers-disease-an-overview).
- [Muscular dystrophy](https://my.clevelandclinic.org/health/diseases/14128-muscular-dystrophy).
- [Lou Gehrig's disease](https://my.clevelandclinic.org/health/diseases/16729-amyotrophic-lateral-sclerosis-als).
- [Diabetes](https://my.clevelandclinic.org/health/diseases/7104-diabetes-mellitus-an-overview).
- [Cancer](https://my.clevelandclinic.org/health/diseases/12194-cancer-overview).
ShowImage.ashx
Mitochondrial Diseases: Causes, Symptoms, Diagnosis & Treatment
my.clevelandclinic.org

[nidan7500]

Thanks again Sokol. This post contains a trove of critical knowledge and facts (IMHO) which helps to link AVXL to the CNS diseases CORE solution.

The Mitochondria–Endoplasmic Reticulum Contacts and Their Critical Role in Aging and Age-Associated Diseases

Ornella Moltedo,1 Paolo Remondelli,2,* and Giuseppina Amodio2,*
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Abstract

The recent discovery of interconnections between the endoplasmic reticulum (ER) membrane and those of almost all the cell compartments is providing novel perspectives for the understanding of the molecular events underlying cellular mechanisms in both physiological and pathological conditions. In particular, growing evidence strongly supports the idea that the molecular interactions occurring between ER and mitochondrial membranes, referred as the mitochondria (MT)–ER contacts (MERCs), may play a crucial role in aging and in the development of age-associated diseases. As emerged in the last decade, MERCs behave as signaling hubs composed by structural components that act as critical players in different age-associated disorders, such as neurodegenerative diseases and motor disorders, cancer, metabolic syndrome, as well as cardiovascular diseases. Age-associated disorders often derive from mitochondrial or ER dysfunction as consequences of oxidative stress, mitochondrial DNA mutations, accumulation of misfolded proteins, and defective organelle turnover. In this review, we discuss the recent advances associating MERCs to aging in the context of ER–MT crosstalk regulating redox signaling, ER-to MT lipid transfer, mitochondrial dynamics, and autophagy.

nlm.nih.gov