Zip, Reduction of amyloid plaque in the brain is not one of the biomarkers being measured in the study. Correct me if you read it differently. I have no idea what effect Vascepa will have on the long term progression of Alzheimer's disease. I investigated the scientific research that led to the trial design. I also checked the most recent FDA guidelines. BRAVE should be a successful clinical trial, and according to FDA guidelines the data should be enough to apply for approval. Sleven,