Replies to post #402869 on Anavex Life Sciences Corp (AVXL)

[boi568]

In the absence of a properly controlled and blinded trial, you can't establish any level of efficacy for Simulfilam.

[williamssc]

SAVA trial is unblinded with no placebo control, this puts them years behind AVXL.

[peeved]

This idea that trials out of the usa are not valid for fda approval has been

Debunked ad nauseum.

If you think a trial without placebo is more valid than an adequate trial outside the usa then you really need to stick with sava

[Mikesc]

Welcome... did you know Anavex was a printing company?

[Amatuer17]

Very good analysis - the question on whether the trial will be accepted in US - interesting angle

[sab63090]

Excellent post and summary of where we are!

[RedShoulder]

they can claim to be the second drug after simufilam that actually improved cognition in mild AD at one year, and puts them a head above Biogen and Lilly.

That is a false statement, the first trial that showed improved cognition was Anavex's Ph-2 trial with some super responders. That was many years ago, way before the simufilam unblinded open label with no placebo trial results.

Another fact that SAVA investors overlook is that simufilam is downstream from the S-1 receptor that will be brought into homeostasis with A2-73 Blarcamesine and properly fold proteins upstream; making simufilam redundant and not needed.