Nuke, MITIGATE isn’t a study to see if IPE can completely prevent COVID and URI’s. It’s looking to see if it reduces symptoms, severity, duration, hospitalization and death. I believe IPE will show some benefit in all categories. I’m basing that on my own health history and the number of exposures I’ve had to COVID and other URI’s over the past 5 to 6 years. All family members in my household and extended family have had COVID and other viral infections multiple times each. None of them take IPE and are much younger than me. I’ve only had COVID once(2022) and had very mild symptoms. Other than that I haven’t had a viral infection or any illness for 5-6 years. FWIW.