not when it is a split face trial. If all 5 notice longer duration, stronger effect and quicker onset, that ends up being pretty significant in most cases. Any physician injecting a neurotoxin that causes 5 out of 5 brow ptosis in their patients will view that as significant. Same here.
Stated otherwise: if 5 people were served 2 different bowls of soup 5 days apart, and all 5 died within 15 minutes of eating bowl of soup 1 but none died after eating bowl of soup 2, most individuals would avoid bowl of soup 1 and infer that it is more likely to kill you than bowl of soup 2.
Same with this, if all 5 subjects see longer duration with one neurotoxin over the other, then most likely this data is real and actionable.
I get that an N of 5 is way too low for a RCT showing significant duration improvement on a 2 point improvement in wrinkle scales. That trial requires N of 150 to 400 typically to power up strong statistical significance.
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