So if 200 responders combined 40 high dose and 160 30 Mg average 3.6 point increase ( mental decline).. Let’s say 80% responded..so 160 of 200 Scored the overall 2.25 average score increase..this means 40 dosed patients Would have to increase by 10 points twice the placebo historical decline in ad..
So.. we did not see and 80% response rate in non high dosed nor in high dosed non responders..
Thinking with as much as TGD focused on high dosage equaling common denominator the 40 high dose did respond .. And the 160 30 Mg patients saw some slowing of symptoms over and above placebo..
Guessing of the 200 dosed low responders They still average better than placebo..but since placebo 4.5 drop.. guessing the 120 high dosed super responders really lift up the numbers..
The OLE of PDD and AD should show the titration to higher dosage the dosing at night and biological evidence of higher S1r expression over time will make over 80% of all participants super duper responders..
Speculation: So if 120 respond 80% at their baseline or better..zero decline.. Then My hypothesis is of the 200 patients left ( 40 in high dose and 160 in 30 Mg ) 100 responded to 2.25 or to overall average increase and 100 responded Very close to placebo..
Think titration to highest dosage as soon as possible is key to expanding The super duper responders ..
Don’t know if lower dosage will be seen as providing benefit because everyone will want to titrated to highest possible dosage as quickly as possible..
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