Replies to post #2955 on Revance Therapeutics Inc (RVNC)

[Dennboy66]

Here is how it works.

Lets say you start with a 50 unit vial.

1. Dilute with 1 ml then you will have 5 units per .1ml. (50/10)
2. Dilute with 4 ml then you will have 1.25 units per ml (50/40)

Lets say that the recommended dosage for the injection site is 10 units.
In scenario 1 you would then need .2ml injected to get 10 units.
In scenario 2 you would then need .8ml injected to get 10 units

With the nature of diffusion, A liquid will typically diffuse from an area of higher concentration to an area of lower concentration. So as you inject more fluid it has to spread out.

In scenario 2 you will get a larger spread as there is more fluid to spread out.

That is how it works. Some MDs like to work with a higher concentration with more injection sites (especially in small treatment areas) unless they are working on a large muscle group like the hamstrings and gastoc-soleus. They like the spread in those muscles. In spasticity, you will always have max dosage and for MDs there is never enough to get everything so they like the spread.