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Replies to post #20760 on Charlotte's Web Holdings Inc (CWBHF)
https://www.gopuff.com/
https://www.gopuff.com/search?q=charlotte%27s+web
On-demand delivery service Gopuff is rolling out its own line of health and wellness products, cofounder Rafael Ilishayev announced onstage at the Forbes Under 30 Summit in Detroit.
Gopuff got big—$15 billion big, per its latest valuation—providing on-demand deliveries for more than 4,000 products, including cleaning and home products, medicine, pet care, office supplies, beauty and wellness products, baby products, food, drinks and alcohol. Founded in 2013 by Forbes Under 30 alumni Ilishayev and Yakir Gola, it currently serves more than a thousand cities and employs more than 7,000 people.
Now, customers can order products such as pain, allergy, cold and flu relief, sleep aid products and at-home diagnostic kits through the company’s in-house label, Goodnow. More products including electrolyte drinks, bandages and antihistamines will roll out in coming months.
CBD Users Report Less Grogginess Than Those on Melatonin Alone
Participants in all study groups saw significant improvements in sleep quality, well-being, anxiety, and pain. The onset of effects from all cannabinoid products were similar to the melatonin control product, with most participants noticing an effect within one hour of taking their product.
Throughout the study, the amount of average increased sleep that participants experienced from each different product ranged from 34 to 76 additional minutes nightly, though there was not a statistically significant difference between products.
The majority (>60%) of participants across all study groups experienced meaningful improvements (defined by “clinically important difference” thresholds) in their sleep.
Seventy-one percent (71%) of participants taking melatonin alone or melatonin in combination with CBD and CBN in a defined ratio also experienced meaningful improvement and 69% of participants taking a combination of CBD, CBN, and CBC in a defined ratio experienced meaningful improvement as well.
All study products exhibited a favorable safety profile. Side effects were mostly mild in nature, and there were no significant differences in the frequency (~10%) of reported side effects between all six study groups. However, the participants receiving products containing cannabinoids (including the product containing cannabinoids + melatonin) reported lower incidences of grogginess than those who received melatonin alone.
Of those who also reported pain and anxiety in addition to sleep disturbance at the start of the study, the greatest proportion of participants who experienced a meaningful improvement in their pain and anxiety were those taking the combination of CBD, CBN, and CBC. This was greater than any other study product (including the melatonin control), though not with a statistically significant difference.
Melatonin Versus CBD for Sleep: Key Takeaways
A blinded, randomized controlled trial to compare cannabinoid products against melatonin finds meaningful improvements in sleep across all products. Results reveal no significant differences in sleep improvement between melatonin compared to all of the cannabinoid-containing products (including those with only cannabinoids and no melatonin) with the exception of one that performed significantly worse than melatonin.
Study results suggest that the combination of certain cannabinoids and melatonin may confer greater improvement in sleep duration than melatonin alone, calling for further research into these combinations—especially given animal studies suggesting interplay between the endocannabinoid system and the pineal gland that produces melatonin.
While the cannabinoid study products had similar incidence of total side effects relative to melatonin, the participants receiving products with cannabinoids (including cannabinoids in combination with melatonin) reported lower incidences of grogginess relative to melatonin only. Therefore, cannabinoid products warrant further attention and research as effective alternatives or additions to melatonin that may avoid or reduce one of its most common and cumbersome side effects.
Moreover, the combination of CBD, CBN, and CBC in a defined ratio may be a particularly promising alternative to melatonin, especially in those who have concurrent pain or anxiety in addition to their sleep disturbance, warranting further exploration.
Charlotte's Web participated in the Radicle ACES (Advancing CBD Education and Science) study, conducted by Radicle Science, an independent health tech company validating health and wellness products. As part of a larger study, hundreds of participants from across the US used Charlotte's Web Original Formula for four weeks and were assessed for key health outcomes across five domains including general well-being, quality of life, sleep quality, feelings of daily stress or discomfort.
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