Replies to post #375914 on Anavex Life Sciences Corp (AVXL)

[Investor2014]

Ah maybe that is what happened in the A2-73 P2a AD trial.

I wonder how many of the patients involved in the Biogen/Eisai AD trial had Cognitive Reserve - which is a compensatory mechanism that actually backs-up brain circuitry and can buffer the effects of losing neurons and synapses to Alzheimer’s (Read the article below. It's truly fascinating!)

Good job that the Biogen/Eisai trial was randomized and placebo controlled, so that any such effect would show in all cohort arms especially in such a large trial.

[kevindenver]

"Cognitive Reserve" definitely makes evaluations difficult and is a very key concept to factor in. Trial design can mitigate it.

I'm coming from the Lewy Body Dementia angle on this. For those interested in this concept I recommend the documentary of Robin Williams, "Robin's Wish".