What do you think about the apparent change of a Phase 2 rather than a Phase 3 being planned for PD? Perhaps it is a question of knowing more about the complexities of the disease; perhaps the recent exome results, after study, may allow for a better designed Phase 3 to be reset.
Although Missling appears willing to gamble at times, such as with a single pivotal AD trial or his expressed intention of going straight to other, similar pivotal trials, I think in his own mind he believes there is little risk.
There is an American saying -- perhaps it is English -- that a good carpenter will measure twice in order to cut just once. That seems to be his style.