Based on these positive safety and PK results, ENTA is advancing the 200mg qD and 400mg qD doses (without ritonavir boosting) to phase-2, which is expected to start in 4Q22.
I haven't seen any PR explaining RVNC pullback today.
I haven't looked at what they've been presenting this week;
But you might find something here:
presentations will be live for the duration of the TOXINS Conference and available for conference attendees online for six months post-meeting. Complete abstracts, details on presentation times and dates can be found on the TOXINS 2022 website. Please visit:
Revance To Present Clinical Data on DaxibotulinumtoxinA for Injection at the 2022 TOXINS International Conference July 27 2022 - 08:00AM Business Wire Print Tweet Share On Facebook
– New data demonstrating the enhancement of membrane binding of the core neurotoxin of BoNT/A by RTP004, Revance’s novel, excipient peptide –
– A podium presentation on ASPEN-1: A Phase 3 Trial Evaluating the Efficacy, Duration of Effect, and Safety of DaxibotulinumtoxinA for Injection in the Treatment of Cervical Dystonia –
Revance Therapeutics, Inc. (Nasdaq: RVNC), a biotechnology company focused on innovative aesthetic and therapeutic offerings, today announced the presentation of six abstracts to be presented at the 2022 TOXINS International Conference on July 27-30, 2022 in New Orleans, Louisiana.
Among the highlights is a new abstract presenting data demonstrating the enhancement of membrane binding of the core toxin of BoNT/A via Revance’s novel peptide excipient, RTP004. Additionally, data from the ASPEN-1 Phase 3 trial, which evaluated the efficacy, duration of effect, and safety profile of DaxibotulinumtoxinA for Injection in the treatment of cervical dystonia, will be presented by Dr. Cynthia Comella, 2022 President of International Neurotoxin Association (INA). Dr. Comella is a leader in clinical neurotoxin research, and is the author of more than 180 articles, reviews, research papers, abstracts, and books.
“Our latest scientific findings and introduction of new data underscores Revance’s commitment to the advancement of research of neurotoxins in both aesthetic and therapeutic indications, while reinforcing DaxibotulinumtoxinA for Injection’s differentiated performance profile,” said Conor Gallagher, Vice President of Medical Affairs and Scientific Innovation at Revance. “The presentation of this data demonstrates Revance’s drive for innovation in facial aesthetics and supports the strong potential of our therapeutic pipeline in the neurotoxin category. We are pleased to continue to realize the potential of our investigational neurotoxin and share these discoveries with the greater scientific community.”
Posters:
Title: ASPEN-1: A Phase 3 Trial Evaluating the Efficacy, Duration of Effect, and Safety of DaxibotulinumtoxinA for Injection in the Treatment of Cervical Dystonia Authors and Affiliations: Joseph Jankovic, Cynthia Comella, Robert A. Hauser, Atul T. Patel, Todd M. Gross, Roman G. Rubio, Domenico Vitarella, Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX; Rush University Medical Center, Chicago, IL; University of South Florida, Tampa, FL; Kansas City Bone & Joint Clinic, Overland Park, KS; Revance Therapeutics, Inc., Nashville, TN
Title: A Cell-Penetrating Peptide Binds Directly to and Enhances Membrane Binding of the Core Toxin of Botulinum Neurotoxin Serotype A Authors and Affiliations: Michael J. Pulkoski-Gross, Julie Chu, Rainy Shai, Priscilla Too, Revance Therapeutics, Inc., Nashville, TN
Title: DaxibotulinumtoxinA for Injection Demonstrates Consistent Safety and Efficacy in Black Subjects: Subgroup Analysis From a Large, Open Label Repeat-Dose Study Authors and Affiliations: Charles Boyd, Valerie Callender, Cheryl Burgess, Jessica Brown, Conor J. Gallagher, Boyd Beauty, Birmingham MI, Callendar Center for Clinical Research, Glenn Dale, MD, Center for Dermatology and Dermatologic Surgery, Washington, DC, Revance Therapeutics Inc., Nashville, TN
Title: Clinical Immunogenicity of DaxibotulinumtoxinA for Injection in Glabellar Lines Including Subjects With Multiple Exposures: Pooled Data From the Sakura Phase 3 Trials Authors and Affiliations: Shannon Humphrey, Jeffrey S. Dover, Ronald R. Bowsher, Amanda Clancy, Liu, Conor Gallagher, University of British Columbia and Humphrey Cosmetic Dermatology, Vancouver, British Columbia, Canada; Skin Care Physicians, Chestnut Hill, MA; B2S Life Sciences, Franklin, IN; Revance Therapeutics Inc., Nashville, TN
Title: Biochemical Stability and Microbial Control of Reconstituted DaxibotulinumtoxinA for Injection (DAXI) Authors and Affiliations: Mung Bernarndo, Kimberlee Ellis, Thai Thach; Revance Therapeutics Inc., Nashville, TN
Title: A Phase 3, Open-Label, Multicenter Trial to Evaluate the Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia Authors and Affiliations: Jaroslaw Slawek, Peter McAllister, Sebastian Paus, Daniel Truong, Todd M. Gross, Roman G. Rubio, Pat Kesslak, Domenico Vitarella, Al. Jana Pawla, Medical University of Gdansk, Gdansk, Poland; St. Adalbert Hospital, Gdansk, Poland; New England Institute for Neurology and Headache, Stamford, CT, Department of Neurology, University of Bonn, Bonn, Germany; Department of Neurology, GFO Kliniken Troisdorf, Troisdorf, Germany; University of California, Riverside, CA; The Parkinson and Movement Disorder Institute, Fountain Valley, CA; Revance Therapeutics, Inc., Nashville, TN
The above presentations will be live for the duration of the TOXINS Conference and available for conference attendees online for six months post-meeting. Complete abstracts, details on presentation times and dates can be found on the TOXINS 2022 website. Please visit www.neurotoxins.org/toxins-2022 for the latest information.
News 
Market Data 
Discover 
