The unfavorable Nuplazid news from 6/21/22 is still overpowering the SP for that company. sales for the PD psychosis indication have plateaued and they were hoping for AD psychosis. The Nuplazid Advisory board outcome, though not entirely unexpected, could still have gone the other way. The Rett NDA around this date was a given with the only question being June/July or Aug/Sept.
Approval for trofinetide in 2023Q1 will likely occur before TLD release for Anavex Excellence study unless the FDA pushes the date back. Though first to market is always nice, being second to market benefits from the raised awareness to family and doctors. Also, second to market can learn from positives and negatives of the first drug's launch