Support: 888-992-3836
Copyright © 2023 InvestorsHub Inc.
Replies to post #382243 on Amarin Corp Plc (AMRN)
HDGabor
07/04/22 3:53 PM
#382252 RE: Whalatane #382243
MO please link the ones
Mineral oil has been utilized in humans as a laxative for decades (typically in doses of 15–45 g/day)
rosemountbomber
07/04/22 4:31 PM
#382259 RE: Whalatane #382243
Some have also argued that the mineral oil-containing placebo may have raised on-treatment LDL-C levels and increased both atherogenic lipoproteins and C-reactive protein which, in turn, potentially magnified the observed treatment difference between the icosapent ethyl and placebo groups.47 However, even if true, the 5?mg/dL difference in LDL-C in the placebo arm relative to the EPA arm would likely explain at most 3% of the relative risk reduction, which still leaves unexplained a large observed 20–25% risk reduction with EPA. Of note, the authors are presently unaware of any data proving that mineral oil in the minute quantities used in this trial (~2?mL twice daily) would cause cardiovascular harm.