Replies to post #382243 on Amarin Corp Plc (AMRN)

[HDGabor]

K-

MO please link the ones

It is not that, but ...

Mineral oil has been utilized in humans as a laxative for decades (typically in doses of 15–45 g/day)

Best,
G

[rosemountbomber]

Kiwi, I think you know that there are not many trials using MO daily for over 2 years. But anyway you are deviating from my point of you calling 4gm MO a high dose.

Some have also argued that the mineral oil-containing placebo may have raised on-treatment LDL-C levels and increased both atherogenic lipoproteins and C-reactive protein which, in turn, potentially magnified the observed treatment difference between the icosapent ethyl and placebo groups.47 However, even if true, the 5?mg/dL difference in LDL-C in the placebo arm relative to the EPA arm would likely explain at most 3% of the relative risk reduction, which still leaves unexplained a large observed 20–25% risk reduction with EPA. Of note, the authors are presently unaware of any data proving that mineral oil in the minute quantities used in this trial (~2?mL twice daily) would cause cardiovascular harm.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308541/