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Investor2014

06/26/22 5:18 PM

#364540 RE: MayoMobile #364536

Potentially different opinions on the assumptions behind those WGT scores?

WGT = We Got This scores, which I in board lingo assumed your estimates ultimately are? In other words how likely approval is in those various indications.

Those confidence scores must be based on some assumptions that you hold based on all your analysis. What are the assumptions and calculations by which you came to the rather precise estimates below?

My Estimates:

Rett Pediatric Therapy Approval: 95%
Rett Pediatric Disease Mod Approval: 87%

Rett Adult Therapy Approval: 93%
Rett Adult Disease Mod Approval: 81%

PDD Therapy Approval: 96%
PDD Disease Mod Approval: 91%

PD Therapy (no data) Approval: 88%
PD Disease Mod Approval: 79%

Fragile X Therapy (no data) Approval: 93%
Fragile X Disease Mod Approval: 85%

Schizophrenia Therapy (no data) Approval: 81%
Schizophrenia Disease Mod Approval: 72%

Alzheimer’s Therapy Approval: 92%
Alzheimer’s Disease Mod Approval: 90%

FTD Therapy (no data) Approval: 84%
FTD Disease Mod Approval: 80%