Replies to post #360887 on Anavex Life Sciences Corp (AVXL)

[Investor2014]

I thought all biology teachers would know this, but apparently not so here you go.

“Abstract: Ca2+ signaling plays a pivotal role in the control of cellular homeostasis and aberrant regulation of Ca2+ fluxes have a strong impact on cellular functioning. As a consequence of this ubiquitous role, Ca2+ signaling dysregulation is involved in the pathophysiology of multiple diseases including cancer. Indeed, multiple studies have highlighted the role of Ca2+ fluxes in all the steps of cancer progression. In particular, the transfer of Ca2+ at the ER-mitochondrial contact sites, also known as mitochondrial associated membranes (MAMs), has been shown to be crucial for cancer cell survival. One of the proteins enriched at this site is the sigma-1 receptor (S1R), a protein that has been described as a Ca2+-sensitive chaperone that exerts a protective function in cells in various ways, including the modulation of Ca2+ signaling. Interestingly, S1R is overexpressed in many types of cancer even though the exact mechanisms by which it promotes cell survival are not fully elucidated. This review summarizes the findings describing the roles of S1R in the control of Ca2+ signaling and its involvement in cancer progression.”

The risk of over-expressing S1R might need careful consideration.

https://mdpi-res.com/d_attachment/genes/genes-12-00139/article_deploy/genes-12-00139.pdf?version=1611303379

[tredenwater2]

Falconner when I first invested in Anavex I went all the way back in the research papers and presentations the prior CEO had given. I stumbled on a talk whereby their research hypothesized that cancer may use the sigma 1 receptor to spread throughout the body in rare cases. Its been many moons since I looked it up but I believe their cancer shuts down the sigma 1 receptor instead of activating it.

Not much help in supporting evidence but I did see this.

Tred