Missling has never demonstrated any real interest in what investors think, nor has he shown any willingness to do anything differently despite repeated unforced errors. I guarantee you he and his IR folks are well aware of what investors think because that's one of the main jobs of IR. So is communicating that information to management. Missling's attitude seems to have always been love it or leave it. He does not seek input input or constructive criticism from investors. There is simply no check on Missling and that's exactly how he likes it. He uses Anavex to enrich himself at shareholders' expense.
With any luck the stock will do well because the science proves out. I own AVXL for the science in spite of management.
Your heart's in the right place but I assure you they already know what investors think and it makes no difference.