Replies to post #358499 on Anavex Life Sciences Corp (AVXL)

[falconer66a]

Main problem is compromised autophagy, not wastes themselves.

Perhaps clearing mechanisms [of oxidized cholesterol] don't degrade until later in life

Exactly. The problem is not the dietary cholesterol, rather, it’s the fact that for many in older years normal waste-clearing processes, autophagy, no longer work well. All sorts of wastes and bad chemicals then accumulate in neurons, most typically with Alzheimer’s tau and beta-amyloid protein wastes.

Key is this. The problem with Alzheimer’s is not oxidized cholesterol, or tau or beta-amyloid protein wastes. The underlying, basic problem is that with age normal cell-keeping processes, autophagy, are compromised, resulting in all sorts of pathologies; among the worst is Alzheimer’s.

But blarcamesine, by activating the sigma-1 receptor protein, supports or restores autophagic processes. Wastes are cleared from cells before they cause problems; the cells operate normally. (Without side effects, in fact.)