Replies to post #375496 on Amarin Corp Plc (AMRN)

[Whalatane]

gg. We know a lot about the MITIGATE trial design

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843090/

https://rethinkingclinicaltrials.org/news/june-18-2021-the-mitigate-study-insights-from-a-decentralized-virtual-electronic-health-record-based-pragmatic-clinical-trial-andrew-ambrosy-md-alan-go-md/

Re JELIS ...different population , low intensity statins , LDL above 140 mg/dl at baseline , open label etc etc

You know all this

Kiwi

[Jasbg]

ggw, Whala - claps his hands when someone come with a Crap message like this:

This is my biggest fear right now. If MITIGATE does not validate R-It, we are screwed. I think there is no coming back from it if that happens.

Whala is to the extend 'you have to question 'if he is a disciple of Nissen' been 'AGAIN' - and AGAIN' - and AGAIN' trying to connect R-I trial to the mess of the MITIGATE.

I newer understood the need to at all (for someone who trust the science - and results of the R-I trial) to even mention this ground breaking trial - in connection to what seems to a bit of a mess' of what were in beginning a Covid related trial - later mentioned in 10 other relations to just about every group with health problems in America.
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Every so many weeks Whala is - 'Back at It' - trying to draw R-I trial into the MITEGATE mess.

The Short Version: This guy is NOT HELPING Amarin - or any of us - in any way with his endless throwing mud on the long ago closed and acknowledged Reduce It trail.

[Whalatane]

gg. The JELIS secondary prevention curves ( prior MI etc ) DID separate within 1 yr

https://www.researchgate.net/figure/Kaplan-Meier-estimates-of-the-incidence-of-the-primary-endpoint-of-coronary-events_fig3_24409933

Exclude stable angina ...dont think they even considered Angina an endpoint in R-IT did they ...soft endpoint ?

Look at prior MI , prior intervention .......thats a MITIGATE population profile

Kiwi