Replies to post #356128 on Anavex Life Sciences Corp (AVXL)

[Jager997]

Maybe too much swelling... Something they didn't put in the PR:

"There was one death on study, occurring at day 144 in the high-dose Lomecel-B arm."

They didn't report the cause of death.

[nidan7500]

HUH??

So the drug causes the brain to swell? That oughta fix things nicely.

Understand you are making LAB HUMOR of course. I would add that the entire infusion medical/business/treatement process and controls needed makes me want to seriously question the science.

The validation of these schemes and medical devices/processes (part pharma/part medical devices/part ??) is in a dark place on the FDA knowledge based approvals curve. Kind of like the BIIB-AD effort that they bailed on in recent past.

It is IM(scientific)O some scarey shat. Even if you ARE desparate.

[end2war]

Importantly, patients receiving Lomecel-B were not reported to develop a serious side-effect called amyloid-related imaging abnormalities (ARIA) as assessed by magnetic resonance imaging (MRI). Other classes of Alzheimer’s drugs being tested have been reported to cause ARIA.

Whoa there, lets do our reading....

https://investors.longeveron.com/news/News/news-details/2022/Longeveron-Publishes-Peer-Reviewed-Study-of-Phase-1-Trial-Results-of-Lomecel-B-for-Alzheimers-Disease-in-Alzheimers--Dementia-The-Journal-of-the-Alzheimers-Association/default.aspx