Several big drugs have been a success after early initial failures. Erbitux (of Martha Stuart fame) and Herceptin (the HER2+ MBC blockbuster) off the top of my head.
Erg, they would need to inform IRBs for any active trial and consent/reconsent patients accordingly. The trial has not failed…period.
Shorts game is to create doubt and fear, but…
I will not fear Fear is the mindkiller Fear is the little death that leads to total obliteration I will face my fear Allow it to pass over and through me Then, I will turn my minds eye inward to see its path Where fear has gone only I and $10 million will remain.