Replies to post #445461 on NorthWest Biotherapeutics Inc (NWBO)

[BWIS]

You remember dcvax has like a specific maturation level of the d cells

[Lykiri]

DocLee,
Try this one: https://www.mdpi.com/2072-6694/10/10/372/htm

IMO, it shows that it's almost impossible for another group to replicate an effective dendritic cell therapy because they don't possess the 'technology specifics' of DCVax that are proprietary to NWBO.
From the study:

Thirdly, even if a number of groups are working on similar DC vaccination technologies, the production protocols are never exactly the same. One driver is the complexity of the production process that involves multiple steps in Good Manufacturing Practice (GMP) cell processing facilities. Thus, in light of encouraging prior data by other groups [14,15,47,56], the disappointing results of this trial might stem from DC production differences. For instance, DCs in this study were matured with LPS/IFN?, while other groups do not have this step in their production protocol [47,51,56]. Future studies should compare different DC production techniques to clarify the possible relevance of technological specifics. DC production quality per se—following our predefined production protocols and technologies mentioned above—did not seem to be an influencing factor based on the functional DC vaccine analyses that we made (see Section 2. Results).

Interesting remarks from Flipper44

They injected into the node, which, unfortunately, does not allow the natural final dendritic migration activation. (flipper44)

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144037723

Regarding injection internodally versus injection interdermally, and how dendritic cells perform better, activate better, and migrate better when injected intradermally see post sentiment: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144040212

Flipper’s post 192523 about a DC Train: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144041171

[DocLee]

Thanks BWIS & Lykiri for your help. Having read the minutiae of the DC preparation in the article, I can only conclude that NWBO's "secret recipe" (whatever the ingredients and the cooking may be) make the difference between success and failure. I only hope that one day very soon NWBO's secret recipe will be shown to be way more valuable than that of another world (perhaps) leader, Coca Cola. (I, however, prefer Pepsi.)