InvestorsHub Logo

exwannabe

02/08/22 3:20 PM

#442307 RE: jimmy667 #442305

It looks to be a patent covering at a MINIMUM they combination of DCVAX with drugs of the class of Keytuda.


Only in glioblastoma. Not other indications.

NWBO had to remove the broader claims as they could not counter the argument by the examiner that others had already been trialing such combinations.

muee88

02/08/22 3:55 PM

#442319 RE: jimmy667 #442305

Correct, it is a patent covering the combination of DCVax with a check point inhibitor but only for treatment of gliomas. Here is the pending independent claim:

1. (Previously presented) A method of treating a glioma or initiating. enhancing, or prolonging an anti-glioma response in a subject in need thereof comprising administering to the subject a therapcutic agent in combination with an agent that is a checkpoint inhibitor, wherein the therapcutic agent is a dendritic cell vaccine wherein the dendritic cell is pulsed with a glioma antigen, and wherein the agent that is a checkpoint inhibitor is an antibody specific for PD-1, PD-L1, or a fusion protein comprising PD-1 or PD-L1 for targeting PD-L1 or PD-1, or a
combination thereof.

This application will be allowed within the next month or so. After having taken a better look at the most recent rejection, the only issues needing to be taken care of was (1) submission of some “sequence listing” of nucleotide/amino acids (I’m not familiar with this as I do telecommunications type work), (2) fixing of some minor antecedent basis issues in a couple dependent claims, and (3) a filing of a terminal disclaimer to overcome a double patenting rejection. Double patenting rejections are normal and occurs when a company files multiple patent applications with similar subject matter — that is, the current application is rejected in view of another NWBO application, which can be overcome by a terminal disclaimer. A terminal disclaimer just means you’re disclaiming any extended patent term for subject matter in the current application that can find basis in the previously filed application (it is a mechanism to ensure you’re not improperly getting a longer patent term on subject matter that is contained in the previous application by filing this current application).