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blue finch

02/05/22 11:28 AM

#349414 RE: Doc328 #349410

That’s funny but somewhat true apparently

Thanks for continuing to point out stuff that’s obvious to you yet unknown to me and probably others

What a ride owning this has been

georgejjl

02/05/22 2:33 PM

#349462 RE: Doc328 #349410

Doc328: Do you believe that the following is in general true or false???

Alzheimer's disease is easier to treat at the earliest stage possible. See the image below to understand why this is true.



The above is especially true if you are targeting upstream MOA with precision medicine.



The Anavex Blarcamesine Phase 2b/3 trial is for early stage Alzheimer's disease with baseline MMSE scores of 20 to 28 inclusive

Prevention of Alzheimer's disease via Blarcamesine or Anavex 3-71 would be the earliest stage possible.


Good luck and GOD bless

blu_1

02/05/22 6:11 PM

#349482 RE: Doc328 #349410

TY. Very impressive that Avatar bested Lavender considering that the subjects were much older and their disease much further progressed. That's like subjects with moderate Alzheimers besting those w/MCI in drug trials. Impressive! AND the subjects didn't experience the prominent diarrhea and vomiting the Lavender girls did. Those side effects wreck havoc on their already disrupted GI tracts and may lead to malnutrition, weight loss, esophageal erosion, dental caries, insomnia, further mental stress, exhaustion, soiled nappies, filthy bums and vomit strewn about for caregivers to cleanup (gross). Those severe side effects take a toll over time on subjects and caregivers. Probably necessitating having to take a pill just to deal w/the side effects, or eventually needing to discontinue Trofinetide.