Replies to post #346211 on Anavex Life Sciences Corp (AVXL)

[falconer66a]

Blarcamesine against ALS.

...you mention" primary lateral sclerosis, PLS, "-do you think 2-73 could also be beneficial for those suffering with ALS ??

Although the names are similar, PLS (primary lateral sclerosis) and ALS (amyotrophic lateral sclerosis) are rather different.

But I just looked up the causes of ALS.

Research on certain gene mutations suggests that changes in the processing of RNA molecules may lead to ALS-related motor neuron degeneration. RNA molecules are involved with the production of molecules in the cell and with gene activity.

Other gene mutations indicate there may be defects in protein recycling—a naturally occurring process in which malfunctioning proteins are broken down and used to build new working ones. Still others point to possible defects in the structure and shape of motor neurons, as well as increased susceptibility to environmental toxins.

https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet#causes

So, ALS may involve “defects in protein recycling.” That’s a cellular homeostatic process, the autophagy process, where old or deficient cellular components (most of which are proteins) get chemically digested and re-processed or excreted. Blarcamesine facilitates, promotes, or restores autophagy. The drug, then, may prove efficacious against ALS.