Upgrades: Adagio Therapeutics (ADGI) upgraded to Overweight from Equal-Weight at Morgan Stanley; tgt raised to $49 argenx (ARGX) upgraded to Overweight from Neutral at Piper Sandler; tgt raised to $354 Bumble Inc. (BMML) upgraded to Outperform from Mkt Perform at Raymond James; tgt $48 Burlington Stores (BURL) upgraded to Buy from Neutral at Citigroup Copa Holdings (CPA) upgraded to Strong Buy from Outperform at Raymond James; tgt $110 MGP Ingredients (MGPI) upgraded to Buy from Hold at Truist; tgt raised to $100 TJX (TJX) upgraded to Buy from Neutral at Citigroup Downgrades: Alibaba (BABA) downgraded to Buy from Conviction Buy at Goldman; tgt lowered to $215 Beacon Roofing Supply (BECN) downgraded to Hold from Buy at Truist Canadian Pacific (CP) downgraded to Hold from Buy at Deutsche Bank; tgt lowered to $80 Ecopetrol (EC) downgraded to Underweight from Neutral at JP Morgan; tgt $16.50 Merck (MRK) downgraded to Neutral from Buy at Citigroup; tgt lowered to $85 Pinduoduo (PDD) downgraded to Neutral from Buy at Citigroup; tgt lowered to $80 Others: Affirm (AFRM) initiated with a Neutral at Piper Sandler; tgt $127 Allegion (ALLE) initiated with an Overweight at Atlantic Equities; tgt $155 Ecovyst (ECVT) initiated with a Neutral at Citigroup; tgt $10.80 Mirion Technologies (MIR) initiated with a Buy at Goldman; tgt $14