Cortexyme's drug may be helpful to a PG+ population. Obviously that's where they'll focus their phase 3 design. They're gonna have to overcome concerns around the liver AEs. That's a pretty serious potential medical headwind. The company is downplaying it but regulators won't. (For conspiracists: the concerns wouldn't be because of 'FUD', corrupt BP pressure, FDA collusion, cabals, or other nonsense. It would be because of liver enzyme data.)