Replies to post #333678 on Anavex Life Sciences Corp (AVXL)

[plexrec]

" I doubt that Missling would have made his claim of prophylaxis without internal murine trials that show prophylaxis."--TGD was not at all vague about this at the 2 min mark of the recent presentation--animals given 2-73 for 7 days in a row did not contract Alzheimer's when injected with the disease in the pre-clinical trial--now to get the same results in humans !!! Preventive drug !!!!!!

[nidan7500]

falconer66a

The Anavex trifecta of just Rett syndrome, Parkinson’s disease dementia, and Alzheimer’s, is just the first regulatory wager the company will win. Bigger ones after 2022.

Even the biggest virtual dot connecting model in the near future medical-bio universe has to start somewhere...congrats falconer...he will be doing CNS dot connecting models using real trial performance data. NOW THAT...boys and girls deserves at least an ATTAWAY.

[frrol]

Not "will", but might. This is biotech (not fantasy land, unfortunately). Before we do invest in a preventative trial, we will likely be testing the hypothesis with 2-73 in AD model mice. And they'll release the results. They don't keep them secret.

As for sleep effects, we have no support for a sleeping pill as you described. We do have initial support that 2-73 improves the sleep of patients whose sleep is impaired by certain CNS conditions. This is very different, so you have to be careful not to conflate them. This is also very different from alleviating symptoms of sleep deprivation, for which a study was done using an S1 agonist some years ago.