Replies to post #379648 on Innovation Pharmaceuticals Inc (IPIX)

[bradfordbros]

Hey Pete interesting last paragraph. My thinking is the mms wouldn’t want too big of a position either way going into results. So your comment stands out and I am hoping you can explain or were you just speculating?

[Lemoncat]

The RBLs did fine. Brilacidin works great in an environment with no systemic side effects. In the clinic it will be a battle between delivering enough Brilacidin to the target while ensuring the systemic side effects are not too great.

Lots of stuff works great in vitro that doesnt work in the clinic. Our very own Prurisol is one example but you can hundreds of others. Dont blame the RBLs.

Go IPIX!

[sunspotter]

"Same with their science measurements, a drug cannot attain a 426SI and not be effective when in prior trials it showed excellent effectiveness (though these trials were more for bacteria, not viruses)."

In at least one reputable study*, remdesivir achieved an SI in excess of 1000, but it's fair to say that in clinical practise, it's a bit meh. Not useless but not amazing.

Then there are many compounds that work in vitro against coronaviruses but fail in vivo.

That's not the RBLs' fault, it's just science. Not all test tube results translate into clinical results.

*https://www.news-medical.net/news/20200430/Remdesivir-shows-powerful-activity-against-SARS-CoV-2-in-Vitro.aspx