Replies to post #18053 on Synaptogenix Inc (SNPX)

[sstyles]

Thanks so basically patients with too severe disease progression skewed the results in a negative way by showing no improvement between the two groups: treatment arm and placebo?

[Cyosol]

There are two big questions about the last trial though:

1. Why did the most severe patients not respond to the treatment like the other groups did?
2. Why did the placebo group perform so well?

The first one could be explained by a severe lack of surviving neurons making it impossible to reconstruct the network through synaptogenesis, but the second one? I don't think any AD trial has ever had a placebo group perform so well.