Replies to post #18052 on Synaptogenix Inc (SNPX)

[runncoach]

You would think these trials would compare each individual's test score at enrollment and then again at completion and make efficacy judgements based on this but that isn't exactly how it works, especially when there are multiple groups based on different test score groupings such at MMSE 5-9 and 10-14 for example. This link, even if you only read the first paragraph sums it up well IMO. In our case the baseline variables and placebo variables weren't representative of actual patient improvement. In our case due to degrees of severity of the disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1116277/

It should be noted that an outside group has confirmed from the current trial that this is not happening fwiw.

[Theburg]

Did the company release the statistically significant improvement over baseline numbers for the placebo group after adjusting for baseline imbalances? They did say improvement for the bryostatin group was 4.8 over baseline.