Good summary Sokol.
Maintaining a multitude Homeostasis loops many if not most of which are poorly understood surely is the upstream answer.
Will be exiting to see, unspoiled by any interim look, how well the AD P2b/3 and Rett trials turn out.
Might be a significant step towards better understanding of one part of the homeostasis systems.
Still if we really want to get upstream there will be more to understand and act on regarding life-style and diet.
There is a reason that we have the term life-style diseases that seems to follow humans taken over by the worst of western values. A homeostatic balance between the best of cultures and ways of living might be a big part of the answer, much bigger and better than biotechs and pills.
Missling himself is keen to point out the benefits of a healthy lifestyle and rightly so.