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Brinjal

08/26/21 11:12 AM

#372030 RE: sunspotter #371999

Brilacidin's mechanism is three pronged unlike Remdesivir.

As Farrell and KMBJN succintly discussed at length here recently, the mechanism by which Brilacidin disrupts the viral membrane is unique and is extra-cellular, whereas Remdesivir is intra-cellular which itself presents a problem. Moreover, Brilacidin is anti-inflammatory and anti-bacterial, something that Remdesivir lacks.

A high SI of Remdesivir did enable it to succeed in-vivo and receive an EUA (though the extent of its success is under debate). Isn't there a higher probability for Brilacidin to succeed?

Note: I am not in the bio-medical field, so I used layman's terms to express my understanding. But the gentlemen I referred to above have explained it beautifully elsewhere.
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attilathehunt

08/26/21 12:38 PM

#372059 RE: sunspotter #371999

"previous studies then over 50% of subjects will experience adverse events, some of them serious. "


What could be worse than dying?


Whaaa-whaaa-whaaa
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williamssc

08/26/21 1:10 PM

#372070 RE: sunspotter #371999

1000 SI Not according to Cell Research which compared the following-

Remdesivir SI 129.87
Cloroquine SI 88.5
Favipiravir SI 6.46
Penciclovir SI 4.17
Ribavirin SI 3.65

https://www.nature.com/articles/s41422-020-0282-0

We now know Brilacidin 426 SI

Thanks to those who had posted this earlier.