Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid
"... In summary, we found that Sig-1Rs regulate the turnover of the short-lived cdk activator p35 via myristic acid and thus play important roles in the maintenance of proper tau phosphorylation and axon elongation in the brain...."
Myristic acid hitchhiking on sigma-1 receptor to fend off neurodegeneration
"...Thus, the new finding of Tsai et al. suggests that the Sig-1R apparently provides the myristic acid, by means of myristic acid “hitchhiking” on the Sig-1R that allows p35 to bind to the lipid membrane where p35 can accomplish the balanced or homeostatic activation of cdk5. This ultimately results in the regulation of normal axonal growth and maintenance...."
Food sources of myristic acid include nutmeg, palm kernel, and butter Myristic acid is also important but there are also significant levels of medium-chain fatty acids (C8:0 and C10:0), typically making up about 10–20% of coconut oil.
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